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以生化提取和病理为参考,采用QCT和CSE-MRI对鹅肝脂肪的测定进行验证

日期:2020-11-05 13:11:08浏览次数:

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 Abstract

Objectives This study aimed to validate the accuracy and reliability of quantitative computed tomography (QCT) and chemical
shift encoded magnetic resonance imaging (CSE-MRI) to assess hepatic steatosis.
Methods Twenty-two geese with a wide range of hepatic steatosis were collected. After QCT and CSE-MRI examinations, the
liver of each goose was removed and samples were taken from the left lobe, upper and lower half of the right lobe for biochemical
measurement and histology. Fat percentages by QCT and proton density fat fraction by MRI (MRI-PDFF) were measured within
the sample regions of biochemical measurement and histology. The accuracy of QCT and MR measurements were assessed
through Spearman correlation coefficients (r) and Passing and Bablok regression equations using biochemical measurement as
the "gold standard".
Results Both QCT and MRI correlated highly with chemical extraction [r = 0.922 (p < 0.001) and r = 0.949 (p < 0.001)
respectively]. Chemically extracted triglyceride was accurately predicted by both QCT liver fat percentages (Y = 0.6 + 0.866 × X)
and by MRI-PDFF (Y = -1.8 + 0.773 × X).
Conclusions QCT and CSE-MRI measurements of goose liver fat were accurate and reliable compared with biochemical
measurement.

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