QCT脂肪肝动物研究
日期：2020-04-09 10:04:36浏览次数：

内容说明：

以生化提取和病理为参考，采用QCT和CSE-MR I法测定鹅肝脂肪

Objectives This study aimed to validate the accuracy and reliability of quantitative computed tomography (QCT) and chemical

shift encoded magnetic resonance imaging (CSE-MRI) to assess hepatic steatosis.

Methods Twenty-two geese with a wide range of hepatic steatosis were collected. After QCT and CSE-MRI examinations, the

liver of each goose was removed and samples were taken from the left lobe, upper and lower half of the right lobe for biochemical

measurement and histology. Fat percentages by QCT and proton density fat fraction by MRI (MRI-PDFF) were measured within

the sample regions of biochemical measurement and histology. The accuracy of QCT and MR measurements were assessed

through Spearman correlation coefficients (r) and Passing and Bablok regression equations using biochemical measurement as

the "gold standard".

Results Both QCT and MRI correlated highly with chemical extraction [r = 0.922 (p < 0.001) and r = 0.949 (p < 0.001)

respectively]. Chemically extracted triglyceride was accurately predicted by both QCT liver fat percentages (Y = 0.6 + 0.866 × X)

and by MRI-PDFF (Y = -1.8 + 0.773 × X).

Conclusions QCT and CSE-MRI measurements of goose liver fat were accurate and reliable compared with biochemical

measurement.

QCT脂肪肝动物研究日期：2020-04-09 10:04:36浏览次数：