XChengBONE06

日期：2013-03-21 17:03:49浏览次数：

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　　Abstract

　　Introduction: Bone mineral density and geometry measurements by volumetric quantitative computed tomography (vQCT) have been utilized inclinical research studies of aging,户armacologic intervention and mechanical unloading, but there is relatively little information about theassociation of these measures with hip fracture. To address this issue, we have carried out a study comparing vQCT parameters in elderly Chinesewomen with hip fractures with measurements in age-matched controls.Materials and methods: Forty-five women (mean age 74.71+5.94) with hip fractures were compared to 66 age-matched control subjects (meanage 70.7014.66). vQCT was employed to characterize the volumetric bone mineral density in cortical, trabecular, and integral volumes of interestin the proximal femur. In addition to the volume of interest measurements, we computed the cross-sectional areas of the femoral neck andinteitrochanteric planes, the femoral neck axis length, indices of femoral neck bending and compressive strength, and measures of femoral neckcortical geometry. To determine ifcortical geometry measures were associated with hip fracture independently of trabecular vBMD, we carried outmulti-variate analyses including these parameters in a logistic regression modelResults and conclusions: All vQCr measurements discriminated between fractured subjects and age-matched controls. There was .significantdifference in predictive strength between volumetric and areal representations of BMD and trabecular and integral vBMD showed comparablediscriminatory power, although both of these measures were more correlated to fracture status than cortical vBMD. We found that fracturedsubjects had larger femoral neck cross-sectional areas, consistent with adaptation to lower BMD in these osteoporotic subjects. The larger neckcross-sectional areas resulted in bending strength indices in the fractured subjects that were comparable or larger than those of the control subjects.In multi-variate analyses, reduced femoral neck cortical thickness and buckling ratio indices were associated with fracture status independently oftrabecular vBMD.

　　02006 Elsevier Inc. All rights reserved.

　　Bone QCI; Bone dcnsitanctry; Qstcopoross; Hip fracture

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